Carboxylic Ester Hydrolases in Bacteria: Active Site, Structure, Function and Application
نویسندگان
چکیده
منابع مشابه
Carboxylic ester hydrolases of rat pancreatic juice.
An attempt was made to establish the number and characteristics of the enzymes in pancreatic juice that hydrolyze nitrogen- and phosphorus-free esters of fatty acids. For this purpose model compounds were hydrolyzed by lyophilized rat pancreatic juice under conditions that accelerated or inhibited the reactions. Although it is not established with certainty, it is suggested that three enzymes a...
متن کاملA study of carboxylic ester hydrolases: structural classification, properties, and database
The carboxylic ester hydrolases (CEHs) are enzymes that hydrolyze an ester bond to form a carboxylic acid and an alcohol. They are one of the enzyme groups that are most explored industrially for their applications in the food, flavor, pharmaceutical, organic synthesis, and detergent industries. We classified CEHs into families and clans according to their amino acid sequences (primary structur...
متن کاملStructure-Function Studies of Epoxide Hydrolases
Epoxides are three-membered cyclic ethers formed in cells via several metabolic pathways. Epoxide hydrolases (EHs) are enzymes that hydrolyse epoxides to the corresponding diols. The main goal of this thesis was to investigate the structures of EHs from the / -hydrolase family. The first part concerns the structural and functional analysis of a protein-water channel found in EHs in many plants....
متن کاملNeutral and acid retinyl ester hydrolases associated with rat liver microsomes: relationships to microsomal cholesteryl ester hydrolases.
We recently reported the presence of a neutral, bile salt-independent retinyl ester hydrolase (REH) activity in rat liver microsomes and showed that it was distinct from the previously studied bile salt-dependent REH and from nonspecific carboxylesterases (Harrison, E. H., and M. Z. Gad. 1989. J. Biol. Chem. 264: 17142-17147). We have now further characterized the hydrolysis of retinyl esters b...
متن کاملApplication of termite hindgut metagenome derived carboxyl ester hydrolases in the modification of cephalosporin substrates
In the pharmaceutical industry, de-acetylated cephalosporins are highly valuable starting materials for producing semi-synthetic β-lactam antibiotics. In this study a fosmid metagenome library from termite hindgut symbionts was screened for carboxyl ester hydrolases capable of de-acetylating cephalosporins. Recombinant Escherichia coli clones with esterolytic phenotypes on tributyrin agar plate...
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ژورنال
عنوان ژورنال: Crystals
سال: 2019
ISSN: 2073-4352
DOI: 10.3390/cryst9110597